I just added a reference document on how to disconnect and then reconnect a USB device (in my case a Yubikey nano) without actually removing the device from the computer. The documentation can be found here.
I have two GnuPG smart cards that I use to store GPG authentication keys on. One is a Yubikey nano, which I keep in my device most of the time, while the other is a Yubikey 5 NFC which I keep on my physical key ring. Often I need to use the GPG keys that are on my 5 NFC but GPG4Win seems to have a real hard time with multiple smart cards plugged into the computer at the same time.
The problem I was having is that the Yubikey nano is really hard to physically remove from the PC (as designed), so when I need the keys on the 5 NFC it is preferable not to have to remove the nano. The above linked documentation describes how i got around this.